Exenatide Acetate

产品详情：

更新时间： 2026-05-24 22:12:39

CAS号：141732-76-5

常用名： 醋酸艾塞那肽

价格：
$198.3/10mg $4809.32/1g

纯度： 99.21%

备货期： 3天

库存： 现货

产品页： http://www.zhaokebio.com

其他详情（用途，包装）：
Exenatide is a 39-amino acid synthetic peptide and the first-in-class incretin mimetic approved for the treatment of type 2 diabetes mellitus. It is a synthetic version of exendin-4, a naturally occurring peptide originally isolated from the salivary secretions of the Gila monster lizard (Heloderma suspectum) by Dr. John Eng in 1992. Unlike GLP-1 analogs such as liraglutide and semaglutide that are modified derivatives of the human GLP-1 sequence, exenatide is a naturally occurring xenopeptide with approximately 53% amino acid sequence homology to human GLP-1(7-36) amide, yet it binds and activates the human GLP-1 receptor with comparable potency. A critical structural feature is the presence of glycine at position 2 (Gly2), replacing the alanine found in native GLP-1. This single substitution confers resistance to cleavage by dipeptidyl peptidase-4 (DPP-4), the enzyme that rapidly inactivates native GLP-1 within 1.5-2 minutes. Following subcutaneous injection, exenatide has a terminal half-life of approximately 2.4 hours, with measurable plasma concentrations persisting for roughly 10 hours.

Exenatide is a full agonist of the GLP-1 receptor (GLP-1R), a class B G protein-coupled receptor (GPCR) widely expressed on pancreatic beta cells, alpha cells, the gastrointestinal tract, central nervous system, heart, kidney, and vasculature. Binding of exenatide to GLP-1R on pancreatic beta cells activates the Gs-alpha/adenylyl cyclase/cAMP/PKA signaling cascade, potentiating glucose-stimulated insulin secretion (GSIS). This insulin secretagogue effect is glucose-dependent: exenatide amplifies insulin release only when blood glucose exceeds fasting levels, conferring a substantially lower risk of hypoglycemia compared to sulfonylureas. Exenatide also suppresses inappropriate glucagon secretion from pancreatic alpha cells, reducing hepatic glucose output. This effect is preserved during hypoglycemia, meaning the counterregulatory glucagon response remains intact. Additionally, exenatide substantially delays gastric emptying, attenuating postprandial glucose excursions. It crosses the blood-brain barrier and activates GLP-1 receptors in the hypothalamic arcuate nucleus and brainstem, promoting satiety and reducing food intake, which contributes to the weight loss observed in clinical trials (typically 2-4 kg). Notably, exenatide restores the first-phase insulin response that is characteristically absent in patients with type 2 diabetes.

供应商信息：

公司名：深圳兆科生物技术有限公司

认证状态： 未认证供应商

商品数： 18件

电话： 0086-19842673490

地址： 坪山区坑梓街道金沙社区锦绣东路22号雷柏中城生命科学园第3分园A栋 208

地区： 深圳市龙岗区

联系人： 张玉君

联系人电话： 19842673490

邮件：jade.cheung@zhaokebio.com

网址：http://www.zhaokebio.com

主要市场：North America, Western Europe, Midde East, South Asia

年贸易额：10,000,000

外贸占销售比例：100%

主要合作伙伴：

公司介绍：
深圳兆科生物科技有限公司作为一家专业的全球采购与供应链解决方案供应商，专注于提供高品质的肽类原料药服务。我们并非从事制造业务，而是将核心能力集中于从全球医药领域内的合格供应商处进行战略性采购、严格审核以及可靠地交付优质肽类产品。
我们扮演着连接世界级肽类生产商与北美、欧洲、亚太地区及新兴市场的制药研发企业、研究机构及制造企业之间的关键纽带。我们的使命在于消除采购过程中的复杂性，降低供应风险，并确保在整个采购流程的每个阶段都能保持无可妥协的品质。

其他供应商价格：

2018-01-26 价格：$需询单 Exenatide Acetate

2025-03-24 价格：￥需询单醋酸艾塞那肽

2024-07-15 价格：需询单醋酸艾塞那肽

2026-03-09 价格：￥需询单醋酸艾塞那肽

2023-03-21 价格：￥需询单醋酸艾塞那肽

2017-07-01 价格：￥需询单 Exenatide Acetate

2020-10-26 价格：￥400.0 Exenatide

2018-05-04 价格：￥需询单艾塞那肽

2023-06-21 价格：￥需询单醋酸艾塞那肽

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醋酸艾塞那肽价格

Exenatide Acetate

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