Siramesine.HCl

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发布时间： 2026-07-04 15:07:08

CAS号：224177-60-0

常用名： 西拉美新盐酸盐

价格：
￥需询单/100mg ￥需询单/500mg ￥需询单/1g ￥需询单/5g

纯度： 98.0%

备货期： 需询单

库存： 现货

其他详情（用途，包装）：
用途： Siramesine(Lu 28-179) Hcl is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. IC50 value:Target: sigma-2 receptor; lysosome-destabilizing agentsiramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost [1]. Siramesine, a sigma-2 receptor agonist originally developed as an anti-depressant, can induce cell death in transformed cells through a mechanism involving lysosomal destabilization [2].in vivo: SA4503 or siramesine given jointly with MEM (as well as with AMA) decreased the immobility time in rats. The effect of SA4503 and AMA co-administration was antagonized by progesterone, a sigma1 receptor antagonistic neurosteroid. Combined treatment with siramesine and AMA was modified by neither progesterone nor BD1047 (a novel sigma antagonist with preferential affinity for sigma1 sites) [3] 物理化学性质： CAS号：224177-60-0 常用中文名：西拉美新盐酸盐常用英文名：Siramesine (hydrochloride) 分子式：C30H32ClFN2O 分子量：491.039 密度：N/A 沸点：N/A 熔点：225 °C 闪点：N/A 储存条件：-20℃，干燥，密封

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公司名：长沙福臻生物科技有限公司推荐

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2022-03-04 价格：￥720.9 西拉美新盐酸盐

2024-07-15 价格：需询单 1'-(4-(1-(4-氟苯基)-1H-吲哚-3-基)丁基)-3H-螺环[异苯并呋喃-1,4'-哌啶]盐酸盐

2021-02-06 价格：￥27989.0 Siramesine hydrochloride

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西拉美新盐酸盐价格

Siramesine.HCl

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