白克拉克催化剂

• 常用名: 白克拉克催化剂
• 英文名: White-Clark catalyst
• CAS号: 2226663-68-7
• 分子量: 1154.04
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₂Cl₁₇MnN₈
• 熔点: N/A
• 闪点: N/A

白克拉克催化剂用途

Description This catalyst is useful for late-stage functionalization of complex compounds through C-H amination. This catalyst is highly reactive and selective for amination at benzylic positions. The benzylic amination is highly selective over tertiary amination. In substrates with multiple benzylic sites, the preference is for amination at the least sterically encumbered and most electron rich site, irrespective of bond dissociation energy (BDE). Substrates containing basic nitrogen (tertiary amines, pyridine, benzimidazole) can be effectively protected for the first time using this catalyst with a Brønsted (HBF4) or Lewis acid (BF3), to give remotely aminated products. Late-stage amination has been demonstrated on a series of drugs and drug-like molecules, including citalopram, analogs of estrone and dextromethorphan, and biflavanoids, many of which cannot be accessed by other amination methods due to the presence of basic nitrogens.

白克拉克催化剂名称

• 中文名: 白克拉克催化剂
• 英文名: White-Clark catalyst

白克拉克催化剂物理化学性质

• 分子式: C₃₂Cl₁₇MnN₈
• 分子量: 1154.04

白克拉克催化剂英文别名

• [MnIII(ClPc)]Cl