1432061-73-8

1432061-73-8结构式

中文名	加巴喷丁-d6盐酸盐
英文名	[1-(Aminomethyl)(3,3,4,4,5,5-2H6)cyclohexyl]acetic acid hydrochloride (1:1)
英文别名	Cyclohexane-3,3,4,4,5,5-d6-acetic acid, 1-(aminomethyl)-, hydrochloride (1:1) [1-(Aminomethyl)(3,3,4,4,5,5-2H6)cyclohexyl]acetic acid hydrochloride (1:1)

描述	加巴喷丁-d6(盐酸)是氘标记的加巴喷丁(盐酸)。
相关类别	信号通路 >> 跨膜转运 >> 钙通道研究领域 >> 神经疾病
体外研究	氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Receveur JM, et al. Synthesis and biological evaluation of conformationally restricted Gabapentin analogues. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2329-34. [3]. Parker DA, et al. Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices. Eur J Pharmacol. 2004 Jul 14;495(2-3):137-43. [4]. Stefani A, et al. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology. 1998;37(1):83-91. [5]. Lee BS, et al. Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain. J Korean Med Sci. 2013 Feb;28(2):308-14. [6]. Harden RN, et al. A Phase 2a, Randomized, Crossover Trial of Gabapentin Enacarbil for the Treatment of Postherpetic Neuralgia inGabapentin Inadequate Responders. Pain Med. 2013 Sep 18.