536-21-0

• 常用中文名：去甲苯福林
• 常用英文名：norfenefrine
• CAS号：536-21-0
• 分子式：C₈H₁₁NO₂
• 分子量：153.178
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 肾上腺素能受体
• 发布时间：2018-07-13 15:32:12
• 更新时间：2024-01-16 18:49:23
• 诺非非林是一种口服活性的内源性α-肾上腺素能激动剂,可用于研究女性压力性失禁[1][2]。

名称

• 中文名: 去甲苯福林
• 英文名: 3-(2-Amino-1-hydroxyethyl)phenol
• 英文别名: 7,8-Dihydro-14-hydroxynormorphinone; noroxymorphone; Esbuphon; 3-(2-Amino-1-hydroxyethyl)phenol; 1-(m-hydroxyphenyl)-2-aminoethanol; norfenefrine; 4-Hydroxydihydronormorphinone; a-(Aminomethyl)-3-hydroxybenzene Methanol; 14-Hydroxydihydronormorphinone; 3-[(1RS)-2-amino-1-hydroxyethyl]phenol; DL-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]amine; Zondel; (5|A)-4,5-Epoxy-3,14-dihydroxy-morphinan-6-one; Benzenemethanol, α-(aminomethyl)-3-hydroxy-; norphenylephrine; Stagural; a-(Aminomethyl)-m-hydroxybenzyl Alcohol; Novadral; (5alpha)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one; 1-(3'-hydroxy-phenyl)-2-amino-ethanol; DL-m-Octopamine; N-noroxymorphone; Norphenephrine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 360.7±27.0 °C at 760 mmHg
• 分子式: C₈H₁₁NO₂
• 分子量: 153.178
• 闪点: 172.0±23.7 °C
• 精确质量: 153.078979
• PSA: 66.48000
• LogP: -0.28
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.614
• 储存条件: 库房通风低温干燥

生物活性

• 描述: 诺非非林是一种口服活性的内源性α-肾上腺素能激动剂,可用于研究女性压力性失禁[1][2]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 靶点:

  Adrenergic Receptor[2]

• 体内研究: 诺非非林(1.25-5.00 mg/kg；皮下注射；一次)刺激小鼠呼吸道粘液分泌[1]。动物模型：雄性NMRI小鼠[1]剂量：1.25、2.50和5.00 mg/kg给药：皮下注射,一次结果：刺激气管内酚红分泌。
• 参考文献:

  [1]. Engler H, et al. Tracheal phenol red secretion, a new method for screening mucosecretolytic compounds. J Pharmacol Methods. 1984 Jun;11(3):151-7.

  [2]. Jørgensen L, et al. Acute effect of norfenefrine on the urethral pressure profile in females with genuine stress incontinence. Urol Int. 1991;46(2):176-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DN7250000 CHEMICAL NAME : Benzyl alcohol, alpha-(aminomethyl)-m-hydroxy- CAS REGISTRY NUMBER : 536-21-0 BEILSTEIN REFERENCE NO. : 1211018 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C8-H11-N-O2 MOLECULAR WEIGHT : 153.20 WISWESSER LINE NOTATION : Z1YQR CQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 390 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,217,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,217,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28100 ug/kg TOXIC EFFECTS : Endocrine - hyperglycemia Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,60,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 17400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,217,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 263 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 198 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 459 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 810 mg/kg/90D-C TOXIC EFFECTS : Cardiac - other changes Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,60,1968

合成路线

852159-27-4 ~% 536-21-0

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 974 - 977

100-83-4 ~% 536-21-0

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 974 - 977

857561-03-6 ~% 536-21-0

文献：Monatshefte fuer Chemie, , vol. 84, p. 1021,1030

53313-95-4 ~% 536-21-0

文献：Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 36, # 7 p. 625 - 630

139-27-5 ~% 536-21-0

文献：Monatshefte fuer Chemie, , vol. 84, p. 1021,1030

90005-54-2 ~% 536-21-0

文献：Chimica e l'Industria (Milan, Italy), , vol. 38, p. 93,98

2491-37-4 ~% 536-21-0

文献：Journal of the Chemical Society, , p. 4576 - 4579

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852159-27-4 100-83-4 857561-03-6 53313-95-4
139-27-5 90005-54-2 2491-37-4
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