55294-15-0

• 常用中文名：氯唑啉胺
• 常用英文名：Muzolimine
• CAS号：55294-15-0
• 分子式：C₁₁H₁₁Cl₂N₃O
• 分子量：272.13100
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-07-12 20:17:51
• 更新时间：2024-01-03 15:46:39
• Muzolimine(BAY-g 282)是一种缓慢且持久的利尿剂。Muzolimine在Henle循环中产生利尿剂,并显示出抗高血压作用。Muzolimine可用于心血管疾病的研究[1][2]。

名称

• 中文名: 氯唑啉胺
• 英文名: 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one
• 中文别名: 莫唑胺
• 英文别名: Muzolimina [Spanish]; EINECS 259-573-2; Muzolimina [INN-Spanish]; Muzoliminum [INN-Latin]; 5-amino-2-[1-(3,4-dichloro-phenyl)-ethyl]-1,2-dihydro-pyrazol-3-one; Edrul; BAY G 2821; MUZOLIMINE

物化性质

• 密度: 1.51g/cm3
• 沸点: 401.4ºC at 760 mmHg
• 分子式: C₁₁H₁₁Cl₂N₃O
• 分子量: 272.13100
• 闪点: 196.6ºC
• 精确质量: 271.02800
• PSA: 56.19000
• LogP: 3.13500
• 折射率: 1.666

生物活性

• 描述: Muzolimine(BAY-g 282)是一种缓慢且持久的利尿剂。Muzolimine在Henle循环中产生利尿剂,并显示出抗高血压作用。Muzolimine可用于心血管疾病的研究[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体外研究: Muzolimine(10μM-1 mM)剂量依赖性地抑制Ehrlich细胞中的离子转运[2]。
• 体内研究: Muzolimine(0-18 mg/kg；每周口服7次,持续3个月)对狗有明显的利尿作用[1]。动物模型：3只雄性和3只雌性狗[1]剂量：0、2、6、8和18 mg/kg给药：口服灌胃；每周7次,持续3个月。结果：显示出显著的利尿效果,并增加了狗的饮水量。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UR0370000 CHEMICAL NAME : 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro- CAS REGISTRY NUMBER : 55294-15-0 LAST UPDATED : 199703 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C11-H11-Cl2-N3-O MOLECULAR WEIGHT : 272.15 WISWESSER LINE NOTATION : T5NNV DHJ BY1&R CG DG& EZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1559 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory obstruction Kidney, Ureter, Bladder - urine volume increased REFERENCE : CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 221 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis REFERENCE : CLNHBI Clinical Nephrology. (Dustri-Verlag Dr. Karl Feistle, Postfach 49, D-8024 Munich-Deisenhofen, Fed. Rep. Ger.) V.1- 1973- Volume(issue)/page/year: 19(Suppl 1),20,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1794 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory obstruction Kidney, Ureter, Bladder - urine volume increased REFERENCE : CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 310 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis REFERENCE : CLNHBI Clinical Nephrology. (Dustri-Verlag Dr. Karl Feistle, Postfach 49, D-8024 Munich-Deisenhofen, Fed. Rep. Ger.) V.1- 1973- Volume(issue)/page/year: 19(Suppl 1),20,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume increased REFERENCE : CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLNHBI Clinical Nephrology. (Dustri-Verlag Dr. Karl Feistle, Postfach 49, D-8024 Munich-Deisenhofen, Fed. Rep. Ger.) V.1- 1973- Volume(issue)/page/year: 19(Suppl 1),20,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory obstruction Kidney, Ureter, Bladder - urine volume increased REFERENCE : CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9 gm/kg/13W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1620 mg/kg/13W-I TOXIC EFFECTS : Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume increased Related to Chronic Data - death REFERENCE : CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 84 mg/kg/4W-I TOXIC EFFECTS : Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - dehydration REFERENCE : CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977