L-同型半胱氨酸结构式
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常用名 | L-同型半胱氨酸 | 英文名 | L-2-AMINO-4-SULFOBUTYRIC ACID |
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| CAS号 | 14857-77-3 | 分子量 | 183.18300 | |
| 密度 | 1.638g/cm3 | 沸点 | N/A | |
| 分子式 | C4H9NO5S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
L-同型半胱氨酸用途L-同型半胱氨酸(L-HCA)是一种内源性兴奋性氨基酸,作为NMDA受体激动剂(EC50:14μM)。L-同型半胱氨酸具有神经毒性,可用于神经疾病的研究[1][2][3]。 |
| 中文名 | L-同型半胱氨酸 |
|---|---|
| 英文名 | L-Homocysteic acid |
| 英文别名 | 更多 |
| 描述 | L-同型半胱氨酸(L-HCA)是一种内源性兴奋性氨基酸,作为NMDA受体激动剂(EC50:14μM)。L-同型半胱氨酸具有神经毒性,可用于神经疾病的研究[1][2][3]。 |
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| 相关类别 | |
| 靶点 |
NMDA Receptor:14 μM (EC50) |
| 体外研究 | L-同型半胱氨酸激活NMDA受体,EC50值为14μM[1]。L-同型半胱氨酸(100μM)在浦肯野细胞中诱导大电流(1.8 nA),该电流对NMDA受体拮抗剂混合物不敏感[1]。L-同型半胱氨酸(250μM,30分钟)在离体鸡胚视网膜中诱导急性兴奋性毒性反应[2]。L-同型半胱氨酸(0-2mM,48小时)在大鼠原代神经元中诱导浓度依赖性神经毒性作用[3]。 |
| 体内研究 | L-同型半胱氨酸(腹腔注射,4-11mmol/kg)在大鼠出生后早期发育期间诱发癫痫发作[4]。L-同型半胱氨酸(腹腔注射,100-1500mg/kg)部分替代NMDA,在Sprague-Dawley大鼠中,分别在1000和560mg/kg剂量下产生61-67%NMDA水平的最大值[5]。动物模型：Wistar品系雄性白化大鼠[4]剂量：4,5.5,8,11 mM/kg给药：腹腔注射,每日14天结果：以4 mmol/kg诱导屈曲发作。导致剧烈的尾巴摆动、旋转和移动。ECoG(皮层电图)活性下降5-9分钟。 |
| 参考文献 |
[4]. P Mares, et al. Convulsant action of D,L-homocysteic acid and its stereoisomers in immature rats. |
| 密度 | 1.638g/cm3 |
|---|---|
| 分子式 | C4H9NO5S |
| 分子量 | 183.18300 |
| 精确质量 | 183.02000 |
| PSA | 126.07000 |
| LogP | 0.45730 |
| 折射率 | 1.56 |
| 储存条件 | 2-8°C，密封，干燥 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
| 海关编码 | 2922499990 |
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详细
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| 文献：Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012 |
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详细
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| 文献：Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012 |
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~%
详细
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| 文献：Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012 |
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L-同型半胱氨酸 14857-77-3 |
| 文献：Watkins,J.C. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 1187 - 1199 |
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~%
详细
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| 文献：Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012 |
|
~%
详细
|
| 文献：Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu Tetrahedron Letters, 1998 , vol. 39, # 9 p. 1009 - 1012 |
|
~%
详细
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| 文献：Nomoto, Shinya; Shimoyama, Akira; Shiraishi, Susumu; Seno, Tomoyuki; Sahara, Denzo Bioscience, Biotechnology and Biochemistry, 1998 , vol. 62, # 4 p. 643 - 649 |
| L-同型半胱氨酸上游产品 4 | |
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| L-同型半胱氨酸下游产品 0 | |
| 海关编码 | 2922499990 |
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| 中文概述 | 2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装 |
| 监管条件 | A.入境货物通关单 B.出境货物通关单 |
| 检验检疫 | P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验 |
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system [formula omitted]over the vesicular glutamate transporter
Bioorg. Med. Chem. Lett. 20 , 2680-3, (2010) A panel of amino acid analogs and conformationally-restricted amino acids bearing a sulfonic acid were synthesized and tested for their ability to preferentially inhibit the obligate cysteine-glutamat... |
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15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ.
J. Neurochem. 124(4) , 536-47, (2013) Astrocytes are critical for the antioxidant support of neurons. Recently, we demonstrated that low level hydrogen peroxide (H(2) O(2) ) facilitates astrocyte-dependent neuroprotection independent of t... |
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Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment.
Orig. Life Evol. Biosph. 41(3) , 201-12, (2011) Original extracts from an unpublished 1958 experiment conducted by the late Stanley L. Miller were recently found and analyzed using modern state-of-the-art analytical methods. The extracts were produ... |
| L-2-Amino-4-sulfobutyric acid |
| (2S)-2-amino-4-sulfobutanoic acid |
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