< 生产厂家价格 >

L-同型半胱氨酸

L-同型半胱氨酸用途

L-同型半胱氨酸(L-HCA)是一种内源性兴奋性氨基酸,作为NMDA受体激动剂(EC50:14μM)。L-同型半胱氨酸具有神经毒性,可用于神经疾病的研究[1][2][3]。

点击显示

L-同型半胱氨酸名称

[ CAS 号 ]:
14857-77-3

[ 中文名 ]:
L-同型半胱氨酸

[ 英文名 ]:
L-2-AMINO-4-SULFOBUTYRIC ACID

[英文别名 ]:

L-2-Amino-4-sulfobutyric acid
(2S)-2-amino-4-sulfobutanoic acid

L-同型半胱氨酸生物活性

[ 描述 ]:

L-同型半胱氨酸(L-HCA)是一种内源性兴奋性氨基酸,作为NMDA受体激动剂(EC50:14μM)。L-同型半胱氨酸具有神经毒性,可用于神经疾病的研究[1][2][3]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[ 靶点 ]

NMDA Receptor:14 μM (EC50)

[体外研究]

L-同型半胱氨酸激活NMDA受体,EC50值为14μM[1]。L-同型半胱氨酸(100μM)在浦肯野细胞中诱导大电流(1.8 nA),该电流对NMDA受体拮抗剂混合物不敏感[1]。L-同型半胱氨酸(250μM,30分钟)在离体鸡胚视网膜中诱导急性兴奋性毒性反应[2]。L-同型半胱氨酸(0-2mM,48小时)在大鼠原代神经元中诱导浓度依赖性神经毒性作用[3]。

[体内研究]

L-同型半胱氨酸(腹腔注射,4-11mmol/kg)在大鼠出生后早期发育期间诱发癫痫发作[4]。L-同型半胱氨酸(腹腔注射,100-1500mg/kg)部分替代NMDA,在Sprague-Dawley大鼠中,分别在1000和560mg/kg剂量下产生61-67%NMDA水平的最大值[5]。动物模型：Wistar品系雄性白化大鼠[4]剂量：4,5.5,8,11 mM/kg给药：腹腔注射,每日14天结果：以4 mmol/kg诱导屈曲发作。导致剧烈的尾巴摆动、旋转和移动。ECoG(皮层电图)活性下降5-9分钟。

[参考文献]

[1]. M Yuzaki, et al. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J Neurophysiol . 1999 Nov;82(5):2820-6.

[2]. J W Olney, et al. L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull. 1987 Nov;19(5):597-602.

[3]. B Lockhart, et al. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res. 2000 Feb 14;855(2):292-7.

[4]. P Mares, et al. Convulsant action of D,L-homocysteic acid and its stereoisomers in immature rats.

[5]. Katherine L Nicholson, et al. The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology (Berl). 2009 Apr;203(2):441-51.

L-同型半胱氨酸物理化学性质

[ 密度 ]:
1.638g/cm3

[ 分子式 ]:
C₄H₉NO₅S

[ 分子量 ]:
183.18300

[ 精确质量 ]:
183.02000

[ PSA ]:
126.07000

[ LogP ]:
0.45730

[ 折射率 ]:
1.56

[ 储存条件 ]:
2-8°C，密封，干燥

L-同型半胱氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2922499990

L-同型半胱氨酸合成路线

详细合成路线

L-同型半胱氨酸上下游产品

L-同型半胱氨酸上游产品

L-同型半胱氨酸下游产品

L-同型半胱氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

L-同型半胱氨酸文献

Conformationally-restricted amino acid analogues bearing a distal sulfonic acid show selective inhibition of system [formula omitted]over the vesicular glutamate transporter

Bioorg. Med. Chem. Lett. 20 , 2680-3, (2010)

A panel of amino acid analogs and conformationally-restricted amino acids bearing a sulfonic acid were synthesized and tested for their ability to preferentially inhibit the obligate cysteine-glutamat...

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ.

J. Neurochem. 124(4) , 536-47, (2013)

Astrocytes are critical for the antioxidant support of neurons. Recently, we demonstrated that low level hydrogen peroxide (H(2) O(2) ) facilitates astrocyte-dependent neuroprotection independent of t...

Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment.

Orig. Life Evol. Biosph. 41(3) , 201-12, (2011)

Original extracts from an unpublished 1958 experiment conducted by the late Stanley L. Miller were recently found and analyzed using modern state-of-the-art analytical methods. The extracts were produ...

更多文献