134523-01-6

134523-01-6 structure

Name: Atorvastatin Sodium
Chemical Name: atorvastatin sodium
CAS Number: 134523-01-6
Molecular Formula: C₃₃H₃₄FN₂NaO₅
Molecular Weight: 580.62
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-05-22 08:00:00
Modify Date: 2024-01-08 06:42:00
Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4][5].

Name	atorvastatin sodium
Synonyms	1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, sodium salt, (βR,δR)- (1:1) Atorvastatin Sodium Sodium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate atorvastatin sodium salt 3R,5R-Atorvastaatin Sodium salt

Description	Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
References	[1]. Br J Pharmacol. 2006 Sep;149(1):14-22. [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. [5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. [6]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

Density	1.2±0.1 g/cm3
Boiling Point	722.2±60.0ºC at 760 mmHg
Molecular Formula	C₃₃H₃₄FN₂NaO₅
Molecular Weight	580.62
Flash Point	390.6±32.9ºC
Exact Mass	580.234924
PSA	114.62000
LogP	5.05190

Precursor 9
134395-00-9 134523-00-5 849928-46-7 125971-95-1
697266-12-9 125971-94-0 125995-03-1 472967-95-6
1146977-93-6
DownStream 1
134523-00-5

134523-01-6	131275-93-9
501121-34-2	1391052-00-8
1428118-38-0	148217-40-7
222412-87-5	873950-18-6
581772-29-4	344920-08-7