BioBioPha
China
Product Name: Veratric acid
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Veratric acid
Price: ￥78.0/25g ￥218.0/100g ￥708.0/500g ￥178.0/20mg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 3,4-Dimethoxybenzoic acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4-Dimethoxybenzoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 3,4-dimethoxybenzoic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

93-07-2

93-07-2 structure

Name: Veratric acid
Chemical Name: 3,4-dimethoxybenzoic acid
CAS Number: 93-07-2
Molecular Formula: C₉H₁₀O₄
Molecular Weight: 182.173
Catalog: Chemical reagent Organic reagent Aromatic acid
Create Date: 2018-09-17 22:13:13
Modify Date: 2024-01-02 11:49:31
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].

Name	3,4-dimethoxybenzoic acid
Synonyms	MFCD00002500 EINECS 202-215-7 Benzoic acid, 3,4-dimethoxy- 3,4-Dimethoxybenzoic acid Veratric acid

Description	Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology Research Areas >> Cardiovascular Disease
Target	COX-2[3]
In Vitro	Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells[1]. Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis[3]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
In Vivo	Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats[2].
References	[1]. Choi WS, et al. Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. Int J Mol Med. 2015 Jan;35(1):202-10. [2]. Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94. [3]. Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19.

Density	1.2±0.1 g/cm3
Boiling Point	302.9±22.0 °C at 760 mmHg
Melting Point	179-182 °C(lit.)
Molecular Formula	C₉H₁₀O₄
Molecular Weight	182.173
Flash Point	120.9±15.8 °C
Exact Mass	182.057907
PSA	55.76000
LogP	1.99
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.533
Storage condition	Refrigerator
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG8598750

CHEMICAL NAME :: Benzoic acid, 3,4-dimethoxy-

CAS REGISTRY NUMBER :: 93-07-2

BEILSTEIN REFERENCE NO. :: 0518285

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H10-O4

MOLECULAR WEIGHT :: 182.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DG8598750
HS Code	2918990090

Precursor 10
93-03-8 120-14-9 90807-80-0 99-50-3
64-17-5 77-78-1 1131-62-0 2150-38-1
114131-33-8 10535-17-8
DownStream 10
111427-22-6 4302-52-7 3897-89-0 498-00-0
93-03-8 5653-46-3 3943-77-9 3943-74-6
37527-66-5 4143-62-8

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

93-07-2	91-52-1
1521-38-6	42923-56-8
1162658-12-9	20624-87-7
1916-08-1	519-05-1
40163-56-2	2150-38-1