DC Chemicals Limited
China
Product Name: LCH 7749944
Price: $550.0/100mg $950.0/250mg $1900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

796888-12-5

796888-12-5 structure

Name: LCH-7749944
Chemical Name: N-[2-(3-methoxyanilino)-4-quinazolinyl]-N-(tetrahydro-2-furanylmethyl)amine
CAS Number: 796888-12-5
Molecular Formula: C₂₀H₂₂N₄O₂
Molecular Weight: 350.414
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-11 14:13:41
Modify Date: 2024-01-12 08:46:23
LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].

Name	N-[2-(3-methoxyanilino)-4-quinazolinyl]-N-(tetrahydro-2-furanylmethyl)amine
Synonyms	N2-(3-Methoxyphenyl)-N4-(tetrahydro-2-furanylmethyl)-2,4-quinazolinediamine 2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]- N-[2-(3-methoxyanilino)-4-quinazolinyl]-N-(tetrahydro-2-furanylmethyl)amine

Description	LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> PAK Signaling Pathways >> Cell Cycle/DNA Damage >> PAK
Target	PAK4:14.93 μM (IC50)
In Vitro	LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner[1]. LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells[1]. LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase[1]. LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: MKN-1, BGC823, SGC7901 and MGC803 human gastric cancer cells Concentration: 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 μM Incubation Time: 24 hours Result: Inhibited the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner. Apoptosis Analysis[1] Cell Line: SGC7901 cells Concentration: 5, 10, 20 μM Incubation Time: 12, 24, 48 hours Result: Induced apoptosis of SGC7901 cells. Cell Cycle Analysis[1] Cell Line: SGC7901 cells Concentration: 5, 10, 20 μM Incubation Time: 12, 24, 48 hours Result: Prominently induced a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. Western Blot Analysis[1] Cell Line: SGC7901 cells Concentration: 5, 10, 20, 30 μM Incubation Time: 24 hours Result: Dramatically decreased levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.
References	[1]. Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32.

Density	1.3±0.1 g/cm3
Boiling Point	580.0±58.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₂N₄O₂
Molecular Weight	350.414
Flash Point	304.6±32.3 °C
Exact Mass	350.174286
LogP	2.18
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.680