1951431-22-3

1951431-22-3 structure

Name: BKI-1369
Chemical Name: BKI-1369
CAS Number: 1951431-22-3
Molecular Formula: C₂₃H₂₇N₇O
Molecular Weight: 417.51
Catalog: Signaling Pathways Anti-infection Parasite
Create Date: 2019-09-09 18:59:51
Modify Date: 2024-02-04 18:54:00
BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves[1].

Name	BKI-1369

Description	BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
Target	IC50: 1.52 μM (hERG)[1]
References	[1]. Lee S, et al. Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis. Antimicrob Agents Chemother. 2018 Jun 26;62(7).

Molecular Formula	C₂₃H₂₇N₇O
Molecular Weight	417.51