844645-08-5
844645-08-5 structure
- Name: JNJ-26070109
- Chemical Name: JNJ-26070109
- CAS Number: 844645-08-5
- Molecular Formula: C23H17BrF2N4O3S
- Molecular Weight: 547.37
- Catalog: Signaling Pathways GPCR/G Protein Cholecystokinin Receptor
- Create Date: 2020-01-12 10:51:50
- Modify Date: 2024-01-17 20:47:44
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A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.
| Name | JNJ-26070109 |
|---|
| Description | A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2; displays >1200-fold selectivity over hCCK1 receptor; has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively; inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats. |
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| References | References 1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36. 2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93. View Related Products by Target Cholecystokinin Receptor |
| Molecular Formula | C23H17BrF2N4O3S |
|---|---|
| Molecular Weight | 547.37 |