DC Chemicals Limited
China
Product Name: DHODH-IN-11
Price: $500.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1263303-95-2

1263303-95-2 structure

1263303-95-2 structure

Name: DHODH-IN-11
Chemical Name: DHODH-IN-11
CAS Number: 1263303-95-2
Molecular Formula: C₁₅H₁₁N₃O₂
Molecular Weight: 265.27
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2020-04-07 15:09:08
Modify Date: 2024-01-10 13:24:09
DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].

Name	DHODH-IN-11

Description	DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase Research Areas >> Inflammation/Immunology
Target	pKa: 5.03 (DHODH)[1]
In Vitro	Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].
References	[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.

Molecular Formula	C₁₅H₁₁N₃O₂
Molecular Weight	265.27

Hazard Codes	Xi