68252-19-7
68252-19-7 structure
- Name: Pirmenol
- Chemical Name: Pirmenol
- CAS Number: 68252-19-7
- Molecular Formula: C22H30N2O
- Molecular Weight: 338.48600
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2018-08-14 12:40:15
- Modify Date: 2024-01-04 20:32:39
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Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation[1][2][4].
| Name | Pirmenol |
|---|---|
| Synonyms |
2-Pyridinemethanol,a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-,rel-(9CI)
2-Pyridinemethanol,a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-,cis-(+-) 4-[(2S,6R)-2,6-dimethylpiperidin-1-yl]-1-phenyl-1-pyridin-2-ylbutan-1-ol |
| Description | Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation[1][2][4]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.1 μM (IK.ACh)[1] |
| In Vitro | Pirmenol (1 μM) inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells[1]. Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes[3]. Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers[3]. |
| In Vivo | Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4]. Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2]. Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2]. Animal Model: Conscious, coronary artery ligated dogs[4] Dosage: Oral administration (p.o.) Administration: 2.5 and 5 mg/kg Result: Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin. |
| Density | 1.046g/cm3 |
|---|---|
| Boiling Point | 499.6ºC at 760 mmHg |
| Molecular Formula | C22H30N2O |
| Molecular Weight | 338.48600 |
| Flash Point | 256ºC |
| Exact Mass | 338.23600 |
| PSA | 36.36000 |
| LogP | 4.29850 |
| Index of Refraction | 1.547 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |