CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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YS6650000
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CHEMICAL NAME :
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Urea, 1-((p-chlorophenyl)sulfonyl)-3-propyl-
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CAS REGISTRY NUMBER :
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94-20-2
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BEILSTEIN REFERENCE NO. :
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2218363
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LAST UPDATED :
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199706
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DATA ITEMS CITED :
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40
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MOLECULAR FORMULA :
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C10-H13-Cl-N2-O3-S
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MOLECULAR WEIGHT :
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276.76
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WISWESSER LINE NOTATION :
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GR DSWMVM3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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14 mg/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Nutritional and Gross Metabolic - changes in potassium Nutritional and Gross Metabolic - metabolic acidosis
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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60 mg/kg
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TOXIC EFFECTS :
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Behavioral - coma Endocrine - hypoglycemia
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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25 mg/kg/5D-I
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TOXIC EFFECTS :
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Blood - other hemolysis with or without anemia
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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300 mg/kg/4W
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TOXIC EFFECTS :
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Blood - granulocytopenia Blood - leukopenia Nutritional and Gross Metabolic - body temperature increase
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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83 mg/kg/25D-I
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TOXIC EFFECTS :
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Gastrointestinal - ulceration or bleeding from large intestine Liver - jaundice, cholestatic
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2150 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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580 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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590 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1100 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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409 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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1039 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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884 mg/kg
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SEX/DURATION :
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female 1-35 week(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetal death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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840 mg/kg
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SEX/DURATION :
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female 9-39 week(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - Apgar score (human only)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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240 mg/kg
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SEX/DURATION :
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female 32-38 week(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - biochemical and metabolic
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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1358 mg/kg
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SEX/DURATION :
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female 1-26 week(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - stillbirth
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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180 mg/kg
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SEX/DURATION :
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female 26-39 week(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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450 mg/kg
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SEX/DURATION :
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female 26-39 week(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - stillbirth
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1 gm/kg
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SEX/DURATION :
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female 9 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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12 gm/kg
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SEX/DURATION :
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female 1-12 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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1800 mg/kg
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SEX/DURATION :
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female 9-14 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetal death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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45 mg/kg
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SEX/DURATION :
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female 1-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
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TYPE OF TEST :
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Sister chromatid exchange
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TYPE OF TEST :
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Sister chromatid exchange
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TYPE OF TEST :
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Micronucleus test
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TYPE OF TEST :
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Sister chromatid exchange
MUTATION DATA
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TEST SYSTEM :
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Rodent - hamster
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DOSE/DURATION :
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7100 ug/kg
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,349,1980 *** REVIEWS *** TOXICOLOGY REVIEW KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972- Volume(issue)/page/year: 10,82,1976 TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,59,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3997 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 311 (estimated) No. of Female Employees: 198 (estimated)
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