135306-85-3
135306-85-3 structure
- Name: (Tyr5,D-Trp6.8.9,Lys-NH2¹⁰)-Neurokinin A (4-10)
- Chemical Name: asp-tyr-d-trp-val-d-trp-d-trp-lys-nh2
- CAS Number: 135306-85-3
- Molecular Formula: C57H68N12O10
- Molecular Weight: 1081.22000
- Catalog: Peptides
- Create Date: 2018-12-29 20:25:02
- Modify Date: 2024-01-02 08:46:49
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Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
| Name | asp-tyr-d-trp-val-d-trp-d-trp-lys-nh2 |
|---|---|
| Synonyms |
L-Asp-L-Tyr-D-Trp-L-Val-D-Trp-D-Trp-L-Lys-NH2
NK2 TACHYKININ RECEPT M.W. 1081.24 C57H68N12O10 (TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10) Men 10376 |
| Description | Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. |
|---|---|
| Related Catalog | |
| Target |
Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1] |
| In Vitro | Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. |
| In Vivo | Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2]. |
| References |
| Density | 1.361 g/cm3 |
|---|---|
| Boiling Point | 1555.4ºC at 760 mmHg |
| Molecular Formula | C57H68N12O10 |
| Molecular Weight | 1081.22000 |
| Flash Point | 894.5ºC |
| Exact Mass | 1080.52000 |
| PSA | 374.63000 |
| LogP | 6.53410 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.672 |
| Storage condition | -20°C |
| Water Solubility | Insuluble (2.3E-3 g/L) (25 ºC) |
| Hazard Codes | N |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |