DC Chemicals Limited
China
Product Name: CI 583
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

67254-91-5

67254-91-5 structure

Name: CI 583
Chemical Name: sodium meclofenamate monohydrate
CAS Number: 67254-91-5
Molecular Formula: C₁₄H₁₂Cl₂NNaO₃
Molecular Weight: 336.14600
Catalog: Signaling Pathways Cytoskeleton Gap Junction Protein
Create Date: 2016-04-08 05:36:29
Modify Date: 2024-01-30 19:22:09
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].

Name	sodium meclofenamate monohydrate
Synonyms	sodium,2-(2,6-dichloro-3-methylanilino)benzoate,hydrate Meclomen UNII-94NJ818U2W Lenidolor Meclodol Meclofenamic acid sodium salt monohydrate

Description	Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> Cytoskeleton >> Gap Junction Protein
Target	Human Endogenous Metabolite
In Vitro	Meclofenamic acid sodium hydrate (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner[1]. Meclofenamic acid sodium hydrate inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins[2]. Meclofenamic acid sodium hydrate inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins[2]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 0, 12.5, 25, 50, 100 μM Incubation Time: 24 h Result: Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.
References	[1]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84. [2]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8. [3]. Lee YT, et al. Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol. 1999 Aug 13;378(3):349-56. [4]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.

Molecular Formula	C₁₄H₁₂Cl₂NNaO₃
Molecular Weight	336.14600
Exact Mass	335.00900
PSA	61.39000
LogP	3.41760

Precursor 0
DownStream 1
3254-79-3

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