2107-77-9

2107-77-9 structure

Name: 4-Methyldaphnetin
Chemical Name: 7,8-dihydroxy-4-methylchromen-2-one
CAS Number: 2107-77-9
Molecular Formula: C₁₀H₈O₄
Molecular Weight: 192.168
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyran compound
Create Date: 2018-04-12 08:00:00
Modify Date: 2024-01-11 11:27:51
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3].

Name	7,8-dihydroxy-4-methylchromen-2-one
Synonyms	4-METHYLDAPHNETIN 7,8-dihydroxy-4-methyl-2H-1-benzopyran-2-one 7,8-Dihydroxy-4-methyl-2H-chromen-2-one 2H-1-Benzopyran-2-one, 7,8-dihydroxy-4-methyl- EINECS 218-290-4 7,8-dihydroxy-4-methyl-chromen-2-one 7,8-DIHYDROXY-4-METHYLCOUMARIN 4-methyl-7,8-dihydroxycoumarin Coumarin,7,8-dihydroxy-4-methyl MFCD00016972 7,8-dihydroxy-4-methyl-2H-2-chromenone 4-Methyldaphnetine

Description	4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Vázquez R, et al. Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor. Biochem Pharmacol. 2013 Jul 15;86(2):210-21. [2]. Jin X, et al. 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression. Neurotox Res. 2015 Apr;27(3):268-74. [3]. Raj HG, et al. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin. Bioorg Med Chem. 1999 Sep;7(9):2091-4.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04864

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%