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肉桂酸甲酯

肉桂酸甲酯用途

主要用于有机合成

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肉桂酸甲酯名称

[ CAS 号 ]:
1754-62-7

[ 中文名 ]:
反式-肉桂酸甲酯

[ 英文名 ]:
methyl (E)-cinnamate

[中文别名 ]:

肉桂酸甲酯

[英文别名 ]:

MFCD00008458
Methyl trans-cinnamate

肉桂酸甲酯生物活性

[ 描述 ]:

肉桂酸甲酯(E)-肉桂酸甲酯(EMC)是从胜田高良姜中分离出来的一种植物化学成分,是一种具有抗炎特性的天然香料化合物。(E)-肉桂酸甲酯广泛用于食品和商品工业[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

肉桂酸甲酯(0~30μM；24小时；MC3T3-E1细胞)显著增加聚(ADP-核糖)聚合酶(PARP)和半胱天冬酶-3的切割形式,同时降低Survivin和Bcl-2的表达水平,显著增加TUNEL阳性和DAPI染色细胞[1]。肉桂酸甲酯(0~30μM；7天；MC3T3-E1细胞)抑制成骨细胞分化[1]。肉桂酸甲酯(1~100μM；24小时和48小时；MC3T3-E1细胞)降低细胞存活率并诱导形态学改变。EMC减少了MAPK信号和细胞迁移[1]。Western Blot分析[1]细胞系：MC3T3-E1细胞浓度：0~30μM孵育时间：24小时结果：显著增加聚ADP核糖聚合酶(PARP)和半胱天冬酶-3的切割形式,凋亡分析[1]细胞系：MC3T3-E1细胞浓度：0~30μM孵育时间：24小时结果：TUNEL阳性和DAPI染色细胞显著增加。细胞分化试验[1]细胞系：MC3T3-E1细胞浓度：0~30μM培养时间：7天结果：抑制成骨细胞分化。

[参考文献]

[1]. Park KR, et al. A Phytochemical Constituent, (E)-Methyl-Cinnamate Isolated from Alpinia katsumadai Hayata Suppresses Cell Survival, Migration, and Differentiation in Pre-Osteoblasts. Int J Mol Sci. 2020;21(10):3700. Published 2020 May 24.

肉桂酸甲酯物理化学性质

[ 密度 ]:
1.078 g/cm3

[ 沸点 ]:
261.9ºC at 760 mmHg

[ 熔点 ]:
34-38ºC

[ 分子式 ]:
C₁₀H₁₀O₂

[ 分子量 ]:
162.18500

[ 闪点 ]:
141.3ºC

[ 精确质量 ]:
162.06800

[ PSA ]:
26.30000

[ LogP ]:
1.87280

[ 外观性状 ]:
无色或白色晶体

[ 蒸汽压 ]:
0.0112mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
2-8°C

肉桂酸甲酯MSDS

详细MSDS(安全技术说明书)

肉桂酸甲酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
GE0190000

肉桂酸甲酯文献

Contribution of cinnamic acid analogues in rosmarinic acid to inhibition of snake venom induced hemorrhage.

Bioorg. Med. Chem. 19 , 2392-6, (2011)

In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic a...

BF3·OEt2-promoted diastereoselective diacetoxylation of alkenes by PhI(OAc)2.

J. Org. Chem. 76(24) , 9997-10004, (2011)

Selective syn and anti diacetoxylations of alkenes have been achieved using a PhI(OAc)(2)/BF(3)·OEt(2) system in the presence and absence of water, respectively. A broad range of substrates including ...

Stoichiometric model of alpha-cyclodextrin complex formation.

J. Pharm. Sci. 69(5) , 564-7, (1980)

The solubility, spectral, and kinetic methods were used to study complexing between alpha-cyclodextrin (ligand, L) and 3,5-dimethoxycinnamic acid, benzalacetone, and methyl cinnamate (substrates, S). ...

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