二氯乙腈
二氯乙腈用途
二氯乙腈名称
[ CAS 号 ]:
3018-12-0
[ 中文名 ]:
二氯乙腈
[ 英文名 ]:
Dichloroacetonitrile
[中文别名 ]:
[英文别名 ]:
- Dichlor-acetonitril
- Acetonitrile,dichloro
- Acetonitrile, 2,2-dichloro-
- Dichloroacetonitrile
- Trichloroacetonitrile
- MFCD00040886
- Dichloromethyl cyanide
- EINECS 221-159-4
- dicloroacetonitrile
二氯乙腈物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
112.5±0.0 °C at 760 mmHg
[ 分子式 ]:
C2HCl2N
[ 分子量 ]:
109.942
[ 闪点 ]:
35.6±0.0 °C
[ 精确质量 ]:
108.948601
[ PSA ]:
23.79000
[ LogP ]:
1.07
[ 外观性状 ]:
透明无色液体
[ 蒸汽压 ]:
21.7±0.2 mmHg at 25°C
[ 折射率 ]:
1.448
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂、酸类分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
二氯乙腈MSDS
二氯乙腈毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AL8465000
- CHEMICAL NAME :
- Acetonitrile, dichloro-
- CAS REGISTRY NUMBER :
- 3018-12-0
- BEILSTEIN REFERENCE NO. :
- 1739029
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C2-H-Cl2-N
- MOLECULAR WEIGHT :
- 109.94
- WISWESSER LINE NOTATION :
- NCYGG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 330 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 270 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1260 mg/kg/14D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in thymus weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2970 mg/kg/90D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 825 mg/kg
- SEX/DURATION :
- female 7-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - live birth index (measured after birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 825 mg/kg
- SEX/DURATION :
- female 7-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 325 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 325 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 20800 nmol/L
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,1065,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991
二氯乙腈安全信息
[ 符号 ]:
GHS02, GHS05, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H226-H302-H314
[ 警示性声明 ]:
P280-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
C:Corrosive;
[ 风险声明 (欧洲) ]:
R10;R22;R34
[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S25-S16
[ 危险品运输编码 ]:
UN 2920 8/PG 2
[ WGK德国 ]:
3
[ RTECS号 ]:
AL8465000
[ 包装等级 ]:
II
[ 危险类别 ]:
3
[ 海关编码 ]:
2926909090
二氯乙腈合成路线
二氯乙腈上下游产品
二氯乙腈上游产品
二氯乙腈下游产品
二氯乙腈制备
1.制法：
于装有搅拌器的反应瓶中，加入氰基乙酸(2)63.8g（0.75mol）、水750mL。于6min内分批加入N-氯代丁二酰亚胺200.3g(1.5mol)。搅拌反应30min后冰浴冷却2h。过滤，滤饼用二氯甲烷洗涤。分出有机层，水层用二氯甲烷提取。合并有机层，依次用5%的氢氧化钠溶液、水洗涤、无水硫酸钠干燥。常压蒸馏，收集110～112℃的馏分，得化合物(1)45～54g,收率55%～65%。
二氯乙腈海关
[ 海关编码 ]: 2926909090
[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
二氯乙腈文献
Environ. Technol. 35(17-20) , 2347-55, (2014)
The formation potential of haloacetonitriles (HANsFP) from chlorination of raw water of the Dez River in Iran was determined. Samples were collected before treatment at an intake of a water treatment ...
Genotoxic activity of five haloacetonitriles: comparative investigations in the single cell gel electrophoresis (comet) assay and the ames-fluctuation test.Environ. Mol. Mutagen. 36(1) , 52-8, (2000)
Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have c...
Exposure to mutagenic disinfection byproducts leads to increase of antibiotic resistance in Pseudomonas aeruginosa.Environ. Sci. Technol. 48(14) , 8188-95, (2014)
Bacterial antibiotic resistance (BAR) in drinking water has become a global issue because of its risks on the public health. Usually, the antibiotic concentrations in drinking water are too low to sel...
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推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥488.0/500g
￥1298.0/100g
联系人：刘佳
产品详情：二氯乙腈
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：二氯乙腈
公司名：山东金悦源新材料有限公司
区域：济南市天桥区
价格：
￥18000.0/1ton
联系人：王思兵
产品详情：二氯乙腈
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相关化合物
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