D-半胱氨酸

D-半胱氨酸用途

D-Cysteine 是半胱氨酸的 D 型异构体,也是一种大肠杆菌生长的有力抑制剂。D-Cysteine 由 D-氨基酸氧化酶介导产生 H2S,并且是针对小脑共济失调的神经保护剂。D-Cysteine 可抑制由变形链球菌和血红链球菌形成的双物种生物膜的生长和致龋性。

点击显示

D-半胱氨酸名称

[ CAS 号 ]:
921-01-7

[ 中文名 ]:
D-半胱氨酸

[ 英文名 ]:
D-Cysteine

[中文别名 ]:

(S)-2-氨基-3-巯基丙酸

[英文别名 ]:

(2S)-2-amino-3-mercaptopropanoic acid
S-cysteine
(D,L)-H-Cys-OH
D-Cystein
MFCD00066461
D-Amino-3-mercaptopropionic acid
(S)-2-amino-3-mercaptopropanoic acid
(2S)-2-amino-3-sulfanylpropanoic acid
EINECS 213-062-0
(S)-2-Amino-3-mercaptopropionic acid

D-半胱氨酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 神经疾病

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Seki T. Availability of D-cysteine as a protectant for cerebellar neurons. Nihon Yakurigaku Zasshi. 2019;154(3):133-137.

[2]. Soutourina J, et al. Role of D-cysteine desulfhydrase in the adaptation of Escherichia coli to D-cysteine. J Biol Chem. 2001 Nov 2;276(44):40864-72.

[3]. Guo X1, et al. Effect of D-cysteine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis. Sci Rep. 2019 Apr 30;9(1):6689.

D-半胱氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
293.9±35.0 °C at 760 mmHg

[ 熔点 ]:
230ºC

[ 分子式 ]:
C₃H₇NO₂S

[ 分子量 ]:
121.158

[ 闪点 ]:
131.5±25.9 °C

[ 精确质量 ]:
121.019745

[ PSA ]:
102.12000

[ LogP ]:
0.23

[ 外观性状 ]:
白色晶体或结晶粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.550

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

D-半胱氨酸MSDS

D-半胱氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29309013

D-半胱氨酸合成路线

D-半胱氨酸上下游产品

D-半胱氨酸上游产品

D-半胱氨酸下游产品

D-半胱氨酸海关

[ 海关编码 ]: 29309013

D-半胱氨酸文献

Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

PLoS ONE 4(5) , e5492, (2009)

The transcription factor Nrf2 is the master regulator of a cellular defense mechanism against environmental insults. The Nrf2-mediated antioxidant response is accomplished by the transcription of a ba...

Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress.

PLoS ONE 10 , e0123711, (2015)

The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-fluoromethyl ketone (z-FA-FMK) readily inhibits anti-CD3-induced human T cell proliferation, whereas the analogue benzyloxycarbonyl-p...

Identification and quantification of antitumor thioproline and methylthioproline in Korean traditional foods by a liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.

J. Pharm. Biomed. Anal. 100 , 58-63, (2014)

A liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric method (LC-APCI-MS/MS) has been developed for the sensitive determination of antitumor thioproline and methyl...

更多文献