二溴甘露醇
二溴甘露醇用途
米托溴醇(Myelobromol；DBM)是甘露醇的溴化类似物,也被称为一种被归类为烷基化剂的抗癌剂。丝裂霉素具有骨髓抑制的潜力,与加速慢性粒细胞白血病中异基因骨髓移植的几种并发症风险显著降低相关[1][2]。
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二溴甘露醇名称
[ CAS 号 ]:
488-41-5
[ 中文名 ]:
二溴甘露醇
[ 英文名 ]:
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL
[中文别名 ]:
[英文别名 ]:
- r54
- 1.6-dibromo-1.6-dideoxy-D-mannitol
- 1,6-dibromo-D-1,6-dideoxy-mannitol
- 1.6-Dibrom-1.6-didesoxy-D-mannit
- dibromannit
- dibromomannitol
- EINECS 207-676-8
- Mielobromol
- mieobromol
- myelobromol
二溴甘露醇生物活性
[ 描述 ]:
米托溴醇(Myelobromol；DBM)是甘露醇的溴化类似物,也被称为一种被归类为烷基化剂的抗癌剂。丝裂霉素具有骨髓抑制的潜力,与加速慢性粒细胞白血病中异基因骨髓移植的几种并发症风险显著降低相关[1][2]。
[ 相关类别 ]:
[体内研究]
在小鼠模型中,丝裂霉素(850 mg/kg；i.p.；单剂量)提高脾细胞对有丝分裂原的敏感性,并促进胸腺再生[2]。动物模型：雌性BALB/c小鼠(8-10周龄)[2]剂量：850 mg/kg；1500 mg/kg(悬浮于5%吐温80盐水中,0.5 mL)给药：腹膜内注射；单剂量结果：850mg/kg剂量对脾细胞对有丝分裂原的体外增殖反应有影响。在1500 mg/kg剂量下,胸腺再生增强,比对照早,开始恢复时间为2周,次全恢复时间为3周。
二溴甘露醇物理化学性质
[ 密度 ]:
2.117g/cm3
[ 沸点 ]:
511.2ºC at 760mmHg
[ 熔点 ]:
176-178°
[ 分子式 ]:
C6H12Br2O4
[ 分子量 ]:
307.96500
[ 闪点 ]:
263ºC
[ 精确质量 ]:
305.91000
[ PSA ]:
80.92000
[ 蒸汽压 ]:
1.37E-12mmHg at 25°C
[ 折射率 ]:
1.622
[ 储存条件 ]:
−20°C
二溴甘露醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OP2800000
- CHEMICAL NAME :
- Mannitol, 1,6-dibromo-1,6-dideoxy-, D-
- CAS REGISTRY NUMBER :
- 488-41-5
- BEILSTEIN REFERENCE NO. :
- 1721919
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 36
- MOLECULAR FORMULA :
- C6-H12-Br2-O4
- MOLECULAR WEIGHT :
- 308.00
- WISWESSER LINE NOTATION :
- E1YQYQYQYQ1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - normocytic anemia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Blood - normocytic anemia Blood - thrombocytopenia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1240 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - normocytic anemia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1380 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2200 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1080 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4950 mg/kg/33D-I
- TOXIC EFFECTS :
- Behavioral - ataxia Liver - other changes Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5460 mg/kg/26W-I
- TOXIC EFFECTS :
- Endocrine - changes in thymus weight Blood - normocytic anemia Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10920 mg/kg/26W-C
- TOXIC EFFECTS :
- Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9750 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7000 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 9-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3900 mg/kg
- SEX/DURATION :
- female 26 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3900 mg/kg
- SEX/DURATION :
- male 26 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Heritable translocation test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rabbit Bone marrow
- DOSE/DURATION :
- 730 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973
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二溴甘露醇安全信息
[ 危害码 (欧洲) ]:
T: Toxic;
[ 风险声明 (欧洲) ]:
45-22
[ 安全声明 (欧洲) ]:
S22;S45;S53;S36/S37/S39
[ WGK德国 ]:
3
[ RTECS号 ]:
OP2800000
[ 海关编码 ]:
2905590090
二溴甘露醇合成路线
二溴甘露醇制备
由D-甘露醇与氢溴酸反应得到二溴甘露醇:
将甘露醇溶解于氢溴酸,加热回流3h。加水稀释并降温至52℃,加入活性炭脱色。过滤,将滤液降温至20℃,搅拌下用碳酸氢钠调节pH1~2,冷冻后甩滤、水洗、氯仿洗涤,真空干燥后用甲醇重结晶、活性炭脱色精制而得成品。收率约36%。
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二溴甘露醇海关
[ 海关编码 ]: 2905590090
[ 中文概述 ]:
2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 包装
[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
推荐生产厂家/供应商：
公司名：上海源溪生物科技有限公司
区域：上海市浦东新区
价格：
￥需询单/1g
联系人：赖经理
产品详情：16dibromo16dideoxyDMannitol
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥17193.0/5g
￥1287.0/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：1,6-二溴-1,6-二脱氧-D-甘露醇
公司名：武汉敬康恩生物医药科技有限公司
区域：武汉市东西湖区
价格：
￥需询单/1g
联系人：周经理
产品详情：1,6-dibromo-1,6-d-didesoxymannitol
公司名：武汉壹加壹生物科技有限公司
区域：武汉市江夏区
价格：
￥需询单/1mg
联系人：刘经理
产品详情：二溴甘露醇
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相关化合物
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