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百里醌

百里醌用途

Thymoquinone 是从 N. sativa 中分离得到的天然产物。Thymoquinone 具有抗氧化、抗炎、抗癌、抗肿瘤活性和保肝作用。

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百里醌名称

[ CAS 号 ]:
490-91-5

[ 中文名 ]:
百里醌

[ 英文名 ]:
Thymoquinone

[中文别名 ]:

[英文别名 ]:

5-Isopropyl-2-methyl-1,4-benzoquinone
2-isopropyl-5-methyl-para-benzoquinone
MFCD00001602
p-Cymene-2,5-dione
Thymoquinone
2-Isopropyl-5-methylcyclohexa-2,5-diene-1,4-dione
Thymoquinon
2-Isopropyl-5-methyl-1,4-benzoquinone
2-isopropyl-5-methylbenzo-1,4-quinone
2-Isopropyl-5-methylbenzoquinone

百里醌生物活性

[ 描述 ]:

Thymoquinone 是从 N. sativa 中分离得到的天然产物。Thymoquinone 具有抗氧化、抗炎、抗癌、抗肿瘤活性和保肝作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Khader M, et al. Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci. 2014 Dec;17(12):950-7.

百里醌物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
232.0±15.0 °C at 760 mmHg

[ 熔点 ]:
167 ºC

[ 分子式 ]:
C₁₀H₁₂O₂

[ 分子量 ]:
164.201

[ 闪点 ]:
103.9±0.0 °C

[ 精确质量 ]:
164.083725

[ PSA ]:
34.14000

[ LogP ]:
2.33

[ 外观性状 ]:
固体;Light yellow to Brown powder to crystal

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.505

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
Very slightly soluble (0.82 g/L) (25 ºC)

百里醌MSDS

详细MSDS(安全技术说明书)

百里醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU5330000

CHEMICAL NAME :: 2,5-Cyclohexadiene-1,4-dione, 2-methyl-5-(1-methylethyl)-

CAS REGISTRY NUMBER :: 490-91-5

BEILSTEIN REFERENCE NO. :: 1939047

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H12-O2

MOLECULAR WEIGHT :: 164.22

WISWESSER LINE NOTATION :: L6V DVJ B1 EY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 20 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 347,37,1995

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百里醌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GU5330000

[ 海关编码 ]:
2914690090

百里醌上下游产品

百里醌上游产品

百里醌下游产品

百里醌制备

暂无

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百里醌海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

百里醌文献

Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer.

Dig. Dis. Sci. 60 , 1067-80, (2015)

The gemcitabine-insensitivity remains the main challenge for pancreatic cancer treatment. Thymoquinone, the predominant bioactive ingredient of Nigella sativa, has been shown to possess promising anti...

Thymoquinone restores radiation-induced TGF-β expression and abrogates EMT in chemoradiotherapy of breast cancer cells.

J. Cell Physiol. 230(3) , 620-9, (2015)

Radiotherapy remains a prime approach to adjuvant therapies in patients with early and advanced breast cancer. In spite of therapeutic success, metastatic progression in patients undergoing therapy, l...

Evaluation of Antioxidant and Antibacterial Potentials of Nigella sativa L. Suspension Cultures under Elicitation.

Biomed Res. Int. 2015 , 708691, (2015)

Nigella sativa L. (family Ranunculaceae) is an annual herb of immense medicinal properties because of its major active components (i.e., thymoquinone (TQ), thymohydroquinone (THQ), and thymol (THY)). ...

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百里醌

百里醌用途

百里醌名称

百里醌生物活性

百里醌物理化学性质

百里醌MSDS

详细MSDS(安全技术说明书)

百里醌毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

百里醌安全信息

百里醌上下游产品

百里醌上游产品

百里醌下游产品

百里醌制备

百里醌海关

百里醌文献

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