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香芹酚

香芹酚用途

Carvacrol 是唇形科植物中的单萜酚类,具有抗氧化、抗炎、抗癌作用。Carvacrol 可导致 G0/G1 细胞周期停滞,下调 Notch-1 和 Jagged-1,诱导凋亡 (apoptosis)。

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香芹酚名称

[ CAS 号 ]:
499-75-2

[ 中文名 ]:
香芹酚

[ 英文名 ]:
5-Isopropyl-2-methylphenol

[中文别名 ]:

[英文别名 ]:

5-Isopropyl-o-cresol
5-Isopropyl-2-Methylphenol
2-methyl-5-(1-methylethyl)phenol
EINECS 207-889-6
MFCD00002236
2-methyl-5-propan-2-ylphenol

香芹酚生物活性

[ 描述 ]:

Carvacrol 是唇形科植物中的单萜酚类,具有抗氧化、抗炎、抗癌作用。Carvacrol 可导致 G0/G1 细胞周期停滞,下调 Notch-1 和 Jagged-1,诱导凋亡 (apoptosis)。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 干细胞及 Wnt 通路 >> Notch

研究领域 >> 炎症/免疫

[参考文献]

[1]. Khan F, et al. Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. Anticancer Agents Med Chem. 2019 Jul 31.

香芹酚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
237.2±9.0 °C at 760 mmHg

[ 熔点 ]:
3-4 °C(lit.)

[ 分子式 ]:
C₁₀H₁₄O

[ 分子量 ]:
150.218

[ 闪点 ]:
106.7±0.0 °C

[ 精确质量 ]:
150.104462

[ PSA ]:
20.23000

[ LogP ]:
3.28

[ 外观性状 ]:
无色或淡黄色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.523

[ 储存条件 ]:
库房低温通风干燥,防明火,高温,与氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong bases, strong oxidizing agents.

[ 水溶解性 ]:
Insoluble

香芹酚MSDS

香芹酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FI1225000

CHEMICAL NAME :: Carvacrol

CAS REGISTRY NUMBER :: 499-75-2

BEILSTEIN REFERENCE NO. :: 1860514

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H14-O

MOLECULAR WEIGHT :: 150.24

WISWESSER LINE NOTATION :: QR B1 EY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,743,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 810 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73300 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands) V.1-19, 1961-81. For publisher information, see IJCREE. Volume(issue)/page/year: 19,1,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952- Volume(issue)/page/year: 3,73,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 3,109,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 161,196,1931

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,366,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,46,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5071 No. of Facilities: 1235 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 7449 (estimated) No. of Female Employees: 979 (estimated)

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香芹酚安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3265 8/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
FI1225000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2907199090

香芹酚合成路线

香芹酚上下游产品

香芹酚上游产品

香芹酚下游产品

香芹酚制备

1.从牛至油、百里香油用碱液制成酚盐将其单离出来。

2.用对伞花烃经磺化成相应的，对伞花烃-2-磺酸，然后经碱熔处理转化为所需的产品。

3.单离法用酚钠盐从百里香油中单离出百里酚。

4.合成法以薄荷脑为原料,在铜、镍催化剂存在下脱氢而成。

5.也可从丙烯出发与间甲酚缩合而成。

6.由多种中草药经提取加工而成。

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香芹酚海关

[ 海关编码 ]: 2907199090

[ 中文概述 ]:
2907199090 其他一元酚. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

香芹酚文献

Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study.

Life Sci. 116(1) , 8-15, (2014)

The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice.Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 2...

Comparison of biological processes induced in HepG2 cells by tert-butyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The influence of carvacrol.

Mutat. Res. 757(1) , 15-22, (2013)

This paper presents comparisons of biological impacts of the oxidants H2O2 and t-BHP on human liver cells, and shows modulation of these effects by the phenolic compound carvacrol. To understand bette...

Activity of essential oil of Lippia triplinervis Gardner (Verbenaceae) on Rhipicephalus microplus (Acari: Ixodidae).

Parasitol. Res. 112(2) , 863-9, (2013)

The objective of this work was to characterize and investigate the acaricidal activity of the essential oil of the aerial parts of Lippia triplinervis at different concentrations on unengorged larvae ...

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香芹酚相关知识

“香芹酚”：天然植物精油抑菌剂

2022-04-17 19:58:01

“香芹酚”：天然植物精油抑菌剂　　美国农业部的“植物化学和植物物种学”背景资料表明，牛至含有30多种抑菌化合物，这些成分里面抑菌能力最好的是香芹酚和百里香酚，不但可以杀死真菌或阻止其生长，同时可以抑制多数细菌的生长，而且这种非特异性的抗菌作用不会让细菌产生抗药性。牛至精油中香芹酚是抵抗有害微生物和...

香芹酚

香芹酚用途

香芹酚名称

香芹酚生物活性

香芹酚物理化学性质

香芹酚MSDS

详细MSDS(安全技术说明书)

香芹酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

香芹酚安全信息

香芹酚合成路线

详细合成路线

香芹酚上下游产品

香芹酚上游产品

香芹酚下游产品

香芹酚制备

香芹酚海关

香芹酚文献

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