三氯乙酸钠
三氯乙酸钠用途
三氯乙酸钠名称
[ CAS 号 ]:
650-51-1
[ 中文名 ]:
三氯乙酸钠
[ 英文名 ]:
Sodium TCA
[中文别名 ]:
[英文别名 ]:
- Trichloroacetic acid sodium salt
- TCA
- Acetic acid, 2,2,2-trichloro-, sodium salt (1:1)
- Sodium trichloroacetic acid
- MFCD00064198
- sodium,2,2,2-trichloroacetate
- EINECS 211-479-2
- Sodium TCA
- Sodium trichloroacetate
- TCA sodium salt
三氯乙酸钠物理化学性质
[ 密度 ]:
1.808g/cm3
[ 沸点 ]:
196.499ºC at 760 mmHg
[ 熔点 ]:
300 °C
[ 分子式 ]:
C2Cl3NaO2
[ 分子量 ]:
185.369
[ 闪点 ]:
66.344ºC
[ 精确质量 ]:
183.886154
[ PSA ]:
40.13000
[ LogP ]:
0.10650
[ 折射率 ]:
1.518
[ 储存条件 ]:
0-6°C
三氯乙酸钠MSDS
三氯乙酸钠毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AJ9100000
- CHEMICAL NAME :
- Acetic acid, trichloro-, sodium salt
- CAS REGISTRY NUMBER :
- 650-51-1
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C2-Cl3-O2.Na
- MOLECULAR WEIGHT :
- 185.36
- WISWESSER LINE NOTATION :
- QVXGGG &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >365 gm/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >10100 mg/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 4280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 3300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 158 gm/kg/1Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 18,318,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8546 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1462 (estimated) No. of Female Employees: 996 (estimated)
三氯乙酸钠安全信息
[ 符号 ]:
GHS07, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H335-H410
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xi:Irritant;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R37;R50/53
[ 安全声明 (欧洲) ]:
S46-S60-S61
[ 危险品运输编码 ]:
UN 3077 9/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
AJ9100000
[ 包装等级 ]:
III
[ 危险类别 ]:
9.0
三氯乙酸钠合成路线
三氯乙酸钠上下游产品
三氯乙酸钠上游产品
三氯乙酸钠下游产品
三氯乙酸钠制备
1.将三氯乙醛和浓硝酸加入反应釜中，加热共溶得三氯乙酸，然后加氢氧化钠水溶液中和，浓缩，结晶，过滤，干燥得产品。反应式如下：
2. 3.2克氢氧化钠溶于12毫升水，冷却后，慢慢倾入含12.8克三氯乙酸的冷却的有侧管的三角瓶中，仅留约工八。的碱备用。·加1滴0.04%溴甲酚绿溶液，借毛细吸管进一步加碱至终点。塞好瓶塞，将瓶子连接吸气泵，瓶子放在蕉气浴的圈中，并用毛巾包裹。蒸发15-20分钟得干的白色块状物，用不锈钢勺弄碎，进一步干燥至恒重，得4.5克。
三氯乙酸钠文献
Dev. Dyn. 244(4) , 591-606, (2015)
Pluripotency, self-renewal, and differentiation are special features of embryonic stem (ES) cells, thereby providing valuable perspectives in regenerative medicine. Developmental processes require a f...
Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.Retrovirology 11 , 118, (2015)
Down-modulation of the CD4 receptor is one of the hallmarks of HIV-1 infection and it is believed to confer a selective replicative advantage to the virus in vivo. This process is mainly mediated by t...
Regulation of phagocytosis and cytokine secretion by store-operated calcium entry in primary isolated murine microglia.Cell. Signal. 27(1) , 177-86, (2015)
Microglia are immune effector cells in the central nervous system that participate in tissue repair, inflammatory responses, and neuronal degeneration. The most important signaling factor in the diffe...
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推荐生产厂家/供应商：
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥128.0/100g
￥453.0/500g
￥55.0/25g
联系人：夏言
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥54.9/25g
￥496.9/500g
￥124.9/100g
￥41.9/5g
联系人：阿拉丁李高志
产品详情：三氯醋酸钠
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相关化合物
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