四溴乙烷
四溴乙烷用途
四溴乙烷名称
[ CAS 号 ]:
79-27-6
[ 中文名 ]:
1,1,2,2-四溴乙烷
[ 英文名 ]:
sym-Tetrabromoethane
[中文别名 ]:
[英文别名 ]:
- Muthmanns liquid
- Acetylene tetrabromide
- Tetrabromoacetylene
- 1,1,2,2,-tetrabromoethane
- Ethane, 1,1,2,2-tetrabromo-
- EINECS 201-191-5
- sym-Tetrabromoethane
- tetrabromo-1,1,2,2 ethane
- Ethane,1,1,2,2-tetrabromo
- 1,1,2,2-Tetrabromoethane
四溴乙烷物理化学性质
[ 密度 ]:
3.0±0.1 g/cm3
[ 沸点 ]:
243.5±0.0 °C at 760 mmHg
[ 熔点 ]:
1 °C
[ 分子式 ]:
C2H2Br4
[ 分子量 ]:
345.653
[ 闪点 ]:
97.0±13.2 °C
[ 精确质量 ]:
341.688965
[ LogP ]:
4.12
[ 外观性状 ]:
无色至淡黄色液体
[ 蒸汽密度 ]:
11.9 (vs air)
[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C
[ 折射率 ]:
1.654
[ 储存条件 ]:
库房通风低温干燥,与食品、氧化剂、酸类分开储运
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, aluminium, magnesium, alkali metals.
[ 水溶解性 ]:
0.63 g/L (20 ºC)
四溴乙烷MSDS
四溴乙烷毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KI8225000
- CHEMICAL NAME :
- Ethane, 1,1,2,2-tetrabromo-
- CAS REGISTRY NUMBER :
- 79-27-6
- BEILSTEIN REFERENCE NO. :
- 1098321
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 49
- MOLECULAR FORMULA :
- C2-H2-Br4
- MOLECULAR WEIGHT :
- 345.68
- WISWESSER LINE NOTATION :
- EYEYEE
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 549 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 269 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 443 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Liver - fatty liver degeneration Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10920 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired Liver - changes in liver weight Blood - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/m3/4H/17W-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired Liver - changes in liver weight Blood - hemorrhage
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14 ppm/7H/14W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 ppm/7H/26W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14 ppm/7H/15W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 14 ppm/7H/15W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 14 ppm/7H/14W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4 ppm/7H/26W-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 gm/kg/74W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 158 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-TWA 14 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 ppm (14 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,248,1971 OSHA PEL (Gen Indu):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (15 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-DENMARK:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-FINLAND:TWA 1 ppm (14 mg/m3);STEL 3 ppm (42 mg/m3) JAN 1993 OEL-FRANCE:TWA 1 ppm (15 mg/m3) JAN 1993 OEL-GERMANY:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (14 mg/m3);STEL 2 ppm (28 mg/m3) JAN 1993 OEL-TURKEY:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 ppm (7 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71401 No. of Facilities: 39 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 440 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71401 No. of Facilities: 172 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 2516 (estimated)
四溴乙烷安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H315-H319-H330-H412
[ 警示性声明 ]:
P260-P273-P284-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T+:Verytoxic;
[ 风险声明 (欧洲) ]:
R26;R36;R52/53
[ 安全声明 (欧洲) ]:
S24-S27-S45-S61-S1/2
[ 危险品运输编码 ]:
UN 2504 6.1/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
KI8225000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29033036
四溴乙烷合成路线
四溴乙烷上下游产品
四溴乙烷上游产品
四溴乙烷下游产品
四溴乙烷制备
1.由乙炔和溴素加成而得。将溴素加入搪玻璃反应锅内，加入少量水以封闭溴素液面。然后从液下徐徐通入乙炔气体，保持在58-62℃，0.02-0.05MPa的条件下通气反应5-7小时，待反应液渐呈黄色即停止反应。将反应液用稀碳酸钠溶液洗涤，再用清水洗涤至中性，分净洗水，得四溴乙烷成品。原料消耗定额：溴素1110kg/t、电石1940kg/t。
2.将净化了的乙炔直接通入事先放入溴素及水的反应器中，控制压力1.9613～4.9033KPa、反应温度<50℃条件下进行反应，然后用稀碱液洗涤，除去上层碱液后，用水洗，制得成品。
四溴乙烷海关
[ 海关编码 ]: 29033036
四溴乙烷文献
Biomacromolecules 16(4) , 1382-9, (2015)
Natural biomolecules are often used to functionalize materials to achieve desired cell-material interactions. However, their applications can be limited owing to denaturation during the material funct...
Polymerization of affinity ligands on a surface for enhanced ligand display and cell binding.Biomacromolecules 15(12) , 4561-9, (2014)
Surfaces functionalized with affinity ligands have been widely studied for applications such as biological separations and cell regulation. While individual ligands can be directly conjugated onto a s...
Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy.FASEB J. 28(12) , 5097-110, (2014)
Expression of microRNA-652 (miR-652) increases in the diseased heart, decreases in a setting of cardioprotection, and is inversely correlated with heart function. The aim of this study was to assess t...
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