奥那司酮

奥那司酮用途

A synthetic, steroidal progesterone receptor (PR) antagonist with reduced antiglucocorticoid activity compared to mifepristone..

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奥那司酮名称

[ CAS 号 ]:
96346-61-1

[ 中文名 ]:
奥那司酮

[ 英文名 ]:
Onapristone

[英文别名 ]:

Onapristonum [Latin]
ZK 299
Onapristona [Spanish]
Onapristone
Onapristone (INN)

奥那司酮物理化学性质

[ 密度 ]:
1.19 g/cm3

[ 沸点 ]:
654.8ºC at 760 mmHg

[ 分子式 ]:
C₂₉H₃₉NO₃

[ 分子量 ]:
449.62500

[ 闪点 ]:
349.8ºC

[ 精确质量 ]:
449.29300

[ PSA ]:
60.77000

[ LogP ]:
5.15570

[ 折射率 ]:
1.615

奥那司酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG2945000

CHEMICAL NAME :: Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(3-hydroxy propyl)-, (11-beta,13-alpha,17-alpha)-

CAS REGISTRY NUMBER :: 96346-61-1

LAST UPDATED :: 199607

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C29-H39-N-O3

MOLECULAR WEIGHT :: 449.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 40,549,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 18 mg/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 35,409,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 mg/kg

SEX/DURATION :: female 30-33 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 41,197,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 mg/kg

SEX/DURATION :: female 8-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 52,187,1995