Novel synthesis of. alpha.-substituted acrylic acids

…, JR Simon, EB Murray, WM Linfield

文献索引：Serota, S.; Simon, J. R.; Murray, E. B.; Linfield, W. M. Journal of Organic Chemistry, 1981 , vol. 46, # 21 p. 4147 - 4151

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被引用次数: 17

摘要

A facile three-step procedure has been developed for the synthesis of a-substituted acrylic acids. In the first step, a carboxylic acid having no a-substituents is condensed with 2-amino- 2-methylpropanol (AMP) to form the corresponding oxazoline. The oxazoline reacts readily with paraformaldehyde to give an intermediate mixture of mono-and dimethyl01 derivatives which upon heating forms the a-methylene derivatives of the oxazoline. The latter, upon ...