Carboxylic acid-catalyzed one-pot synthesis of cyanoacetylureas and their cyclization to 6-aminouracils in guanidine ionic liquid

SS Chavan, RU Shelke, MS Degani

文献索引：Chavan, Sunil S.; Shelke, Rupesh U.; Degani, Mariam S. Monatshefte fur Chemie, 2013 , vol. 144, # 3 p. 399 - 403

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被引用次数: 3

摘要

Abstract A novel, one-pot, carboxylic acid-catalyzed synthesis of cyanoacetylureas via in situ generated ureas and their cyclization to 6-aminouracils in the presence of the guanidine- based ionic liquid 1, 1, 3, 3-tetramethylguanidine lactate [TMG][Lac] is described. The ureas were synthesized from amines and potassium cyanate, which on reaction with cyanoacetic acid in the presence of acetic anhydride in the same pot afforded cyanoacetylureas, which ...