An expeditious route toward pyrazine-containing nucleoside analogues

…, DS Ermolat'ev, EV Van der Eycken

文献索引：Modha, Sachin G.; Trivedi, Jalpa C.; Mehta, Vaibhav P.; Ermolat'ev, Denis S.; Van Der Eyckens, Erik V. Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 846 - 856

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被引用次数: 28

摘要

An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3, 5-dichloropyrazin-2 (1 H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.