Certain derivatives containing the 1, 2-dihydropyrido [3, 4-blpyrazine (l-deaza-7, 8- dihydropteridine) ring system are active against experimental neoplasms in mice. The mechanism of action of these agents has been attributed to the accumulation of cells at mitosis. Identification of the structural features that are necessary for activity was accomplished by evaluation of modified 1-deazapteridines and ring and ring-opened ...
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