Chemical Science

Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1, 1, 3-triaryl-2-azaallyl anions

M Li, B Yücel, J Adrio, A Bellomo, PJ Walsh

文献索引：Li, Minyan; Yuecel, Baris; Adrio, Javier; Bellomo, Ana; Walsh, Patrick J. Chemical Science, 2014 , vol. 5, # 6 p. 2383 - 2391

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被引用次数: 6

摘要

Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium- catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine ...