Aldol Condensation of Esters with Ketones or Aldehydes to Form β-Hydroxy Esters by Lithium Amide. Comparison with the Reformatsky Reaction1

CR Hauser, WH Puterbaugh

文献索引：Hauser; Puterbaugh Journal of the American Chemical Society, 1953 , vol. 75, p. 1068,1069, 1071

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被引用次数: 23

摘要

The Certain of the &hydroxy esters been effected by means of lithium amide. certain cases (eg, with nitro ketones), more generally applicable than the Reformatsky reaction. esters produced in our method were, in general, converted to a, O-unsaturated acids by treatment with mineral acids. t-butyl@-hydroxy esters from aromatic nitro ketones were converted to &hydroxy acids. were dehydrated to form the a,@-unsaturated esters.