A series of (six-membered heteroary1)-substituted 2 (1H)-quinolinones (1) was synthesized, and structure-activity relationships for cardiac stimulant activity were determined. Most compounds were prepared by acidic hydrolysis of a heteroaryl-2-methoxyquinoline obtained by palladium-catalyzed cross-coupling methodology. Direct reaction of a ppidinylzinc reagent with a 6-haloquinolinone also proved successful. In anesthetized dogs, 6-pyridin- ...
