The Journal of Organic Chemistry

Asymmetric Synthesis of 2-Acetyl-4 (5)-(1, 2, 4-trihydroxybutyl) imidazoles

MD Cliff, SG Pyne

文献索引：Cliff, Matthew D.; Pyne, Stephen G. Journal of Organic Chemistry, 1995 , vol. 60, # 8 p. 2378 - 2383

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被引用次数: 36

摘要

Matthew D. Cliff and Stephen G. me * ... Departm.ent of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia ... A method for preparing trihydroxybutyl analogues of the biologically active compound 2-acetyl- 4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) is reported. "his method employs a palladium(0)- catalyzed coupling of l-(ethoxymethyl)-4-iodoimidazole (3a) to functionalized vinylstannane 11, ...