Ethyl 2, 4-dioxo-4-phenylbutyrate: a versatile intermediate for the large-scale preparation of enantiomerically pure α-hydroxy and α-amino acid esters

HU Blaser, S Burkhardt, HJ Kirner, T Mössner…

文献索引：Synthesis, , # 11 p. 1679 - 1682

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被引用次数: 19

摘要

... ethyl 2-hydroxy-4-phenylbutyrate (3, HPB-ester) (Scheme [1] ), [2] we set out to synthesize a series of ... Both enantiomers of Nosyl-3 were synthesized on up to 700 g scale in 99% yield and ... Table [1] and [2] it can be seen that the procedures developed allow the synthesis of >100 ...