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Tetrahedron: Asymmetry

A practical synthesis of ethyl (R)-and (S)-2-hydroxy-4-phenylbutanoate and D-homophenylalanine ethyl ester hydrochloride from L-malic acid

WQ Lin, Z He, Y Jing, X Cui, H Liu, AQ Mi

文献索引:Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587

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被引用次数: 35

摘要

... Tetrahedron: Asymmetry. Volume 12, Issue 11, 4 July 2001, Pages 1583–1587. ... 12 Nucleophilic substitution of ethyl (S)-2-methanesulfonyloxyl-4-phenylbutanoate 7 with potassium acetate in DMF in the presence of 18-crown-6 provided, after hydrolysis, (R)-1 in 47% yield and 74 ...