Potent, orally active imidazo [4, 5-b] pyridine-based angiotensin II receptor antagonists

NB Mantlo, PK Chakravarty, DL Ondeyka…

文献索引：Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2919 - 2922

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被引用次数: 175

摘要

Angiotensin I1 is the principle pressor agent of the renin-angiotensin system (RAS). This system, a proteolytic cascade that regulates hemodynamics and water and electrolyte balance, can contribute to hypertensive states in man. The effecta of the octapeptide angiotensin I1 (AII), which include vasoconstriction, stimulation of aldosterone synthesis and release, cardiac stimulation, and renal reabsorption of sodium, are mediated through ...