Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors

M Jung, Y Lee, M Park, H Kim, H Kim, E Lim…

文献索引：Jung, Mankil; Lee, Yongnam; Park, Moonsoo; Kim, Hanjo; Kim, Heekyeong; Lim, Eunyoung; Tak, Jungae; Sim, Minjoo; Lee, Dongeun; Park, Namsoo; Oh, Won Keun; Hur, Kyu Yeon; Kang, Eun Seok; Lee, Hyun-Chul Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4481 - 4486

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被引用次数: 19

摘要

Dihydroxy stilbene derivatives were designed based on lithospermic acid B and were prepared from 4-(chloromethyl) benzoic acid. The inhibitory activities of the novel compounds against protein tyrosine phosphatase 1B (PTP1B) were evaluated. 3, 4- Dihydroxy stilbene carbonyl compounds (7, 11b, 27b) inhibited PTP1B with IC50 values comparable to molybdate, while the conjugation-extended compound (15b) showed ...