Bioorganic chemistry

Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens

NS Hatzakis, I Smonou

文献索引：Hatzakis, Nikos S.; Smonou, Ioulia Bioorganic Chemistry, 2005 , vol. 33, # 4 p. 325 - 337

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被引用次数: 38

摘要

A new asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens has been found. Although alcohols are not the natural substrates for this enzyme, a high R enantioselectivity was observed. Stereochemical studies showed that variations in substrate structure lead to strong variations in enantioselectivity. The highest enantioselectivities are obtained when the β-carbon of the secondary alcohol is tertiary or ...