Steric course of ketopantoate hydroxymethyltransferase in E. coli

DJ Aberhart, DJ Russell

文献索引：Aberhart, D. John; Russell, David J. Journal of the American Chemical Society, 1984 , vol. 106, # 17 p. 4902 - 4906

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被引用次数: 15

摘要

Abstract: The conversion of a-ketoisovaleric acid (a-KIVA) to ketopantoate by the 5, lO- methylenetetrahydrofolate-dependent enzyme ketopantoate hydroxymethyltransferase (KHMT) in E. coli has been shown to proceed in a retention mode at the P-position of a- KIVA. 5, lO-Methylenetetrahydrofolate formed in vivo by serine hydroxymethyltransferase (SHMT) from stereospecifically deuterated (3S-dl) serine was converted by KHMT into an ...