Preparation and resolution of a modular class of axially chiral quinazoline-containing ligands and their application in asymmetric Rhodium-catalyzed olefin …

…, M McCarthy, CP Saunders, AM Carroll…

文献索引：Connolly, David J.; Lacey, Patrick M.; McCarthy, Mary; Saunders, Cormac P.; Carroll, Anne-Marie; Goddard, Richard; Guiry, Patrick J. Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6572 - 6589

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被引用次数: 82

摘要

The preparation and resolution of a series of axially chiral quinazoline-containing ligands is described in which the key steps are the metal-catalyzed naphthyl-phosphorus bond formation, the naphthalene-quinazoline Suzuki coupling, and the preparation of the Suzuki electrophilic components from the corresponding imidate and anthranilic acid. Diastereomeric palladacycles derived from the racemic phosphinamines and (+)-di-μ- ...