Abstract The partial Lossen degradation of the hydroxamic acid group at C-4 or C-5 of sodium 4, 5-thiazoledicarbohydroxamate (IIIb) and its 2-methyl analog (IIIe) initiated a multicoursed reaction which furnished a mixture of thiazolo [4, 5-d]-and thiazolo [5, 4-d]-N- hydroxyuracils. The isomer distribution was sensitive to the solvent systems in which these reactions were carried out. The structure of the isomers so obtained was established by ...