Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4, 5-unsubstituted imidazole series 6-11 and the 1, 4, 5, 6- tetrahydrocyclopent [d] imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+-ATPase. Structure-activity relationships indicate that the substitution of 2-pyridyl groups at the 1-position of the imidazole moiety combined with (2- ...
