Toward establishing structure–activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells

…, J Jacobs, S Debenedetti, C Shayo, N De Kimpe…

文献索引：Riveiro, Maria E.; Maes, Dominick; Vazquez, Ramiro; Vermeulen, Monica; Mangelinckx, Sven; Jacobs, Jan; Debenedetti, Silvia; Shayo, Carina; De Kimpe, Norbert; Davio, Carlos Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6547 - 6559

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被引用次数: 32

摘要

The presumption that some coumarins might be lead compounds in the search for new differentiation agents against leukemia is based on the fact that natural coumarins, 5-(3- methyl-2-butenyloxy)-6, 7-methylenedioxycoumarin (C-2) and 5-methoxy-6, 7- methylenedioxycoumarin (C-1) inhibit proliferation and induce differentiation in U-937 cells [Riveiro, ME; Shayo, C.; Monczor, F.; Fernandez, N.; Baldi, A.; De Kimpe, N.; Rossi, J.; ...