Synthesis and antitumor activity of N-benzyl-5-fluorouracils

RG Melik-Ogandzhanyan, VÉ Khachatryan…

文献索引：Melik-Ogandzhanyan, R. G.; Khachatryan, V. E.; Gapoyan, A. S.; Okhikyan, V. M.; Papoyan, S. A. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 12 p. 888 - 889 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 12 p. 1468 - 1470

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摘要

In continuation of the search for 5-fluorouracil derivatives of low toxicity [1, 2], we have synthesized some new N-benzyl-5-ftuorouracils (In-e) with a range of substituents in the benzene ring. The choice of compounds (Ia-e) was due to the fact that certain N-substituted uracils have been found to possess high antitumor activity [1-3]. There is also great interest in elucidating the relationship of the biological activity of the N-benzyl-5-fluorouracils to ...