Hypervalent iodine mediated synthesis of 1-aryl/hetryl-1, 2, 4-triazolo [4, 3-a] pyridines and 1-aryl/hetryl 5-methyl-1, 2, 4-triazolo [4, 3-a] quinolines as antibacterial …

AK Sadana, Y Mirza, KR Aneja, OM Prakash

文献索引：Sadana, Anil K.; Mirza, Yasmin; Aneja, Kamal R.; Prakash, Om European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 533 - 536

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被引用次数: 177

摘要

Oxidation of 2-pyridyl and 2-quinylhydrazones with iodobenzene diacetate (IBD) in dichloromethane yield 1-aryl/hetryl-1, 2, 4-trizolo-[4, 3-a] pyridines (3a–f) and 1-aryl/hetryl-5- methyl-1, 2, 4-triazolo [4, 3-a] quinolines (6a–f). Seven compounds were tested in vitro for their antibacterial activity. 1-(5′-Nitro-2-furyl)-5-methyl-1, 2, 4-triazolo [4, 3-a] quinoline (6e) was associated with substantially higher antibacterial activity than some commercial ...