Substituted s-triazolo [4, 3-a] pyridines (2) containing alkyl, aryl, alkylaryl, heteryl, amino, hydroxyl, mercapto, and halogen substituents at position 3 have been synthesized in a study of the chemistry of this ring system, mainly by cyclization of 2-pyridylhydrazines (1) or their derivatives with appropriate reagents, and by modification of groups already present in the 3- position. Methyl substituents have also been placed at all peripheral carbon atoms. Di (3-s ...