Journal of medicinal chemistry

N, N'-(phenylene) dioxamic acids and their esters as antiallergy agents

JB Wright, CM Hall, HG Johnson

文献索引：Wright,J.B. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 930 - 935

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被引用次数: 28

摘要

A series of dialkyl N,”-(m-pheny1ene) dioxamates was synthesized by treatment of the requisite m-phenylenediamines with an alkyloxalyl chloride in the presence of triethylamine, Hydrolysis with sodium hydroxide solution gave the corresponding N, N'-(mpheny1ene) dioxamic acids. Several N, N'-@-pheny1ene) dioxamic acids were synthesized also in the same manner starting with the requisite p-phenylenediamines. These compounds were ...